Ongoing Research Support

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R01NS083983 Blackmore (PI) 7/2013-2/2024

Combinatorial Manipulation of Transcription Factors to Promote CNS Regeneration

This project will test new combinations of transcription factors, including NR5A2, EOMES, and RARB, for the ability to synergize with KLF6 in promoting axon regeneration after injury to the central nervous system. In addition, we will deploy a new retrograde gene delivery system to maximize functional effects.

 

R01NS107807 Blackmore (PI) 7/2018-6/2023

Strategies to Optimize the Function of Regenerated Corticospinal Tract Axons

This grant explores rehabilitation and neural stimulation approaches to improve behavioral outcomes in

animals with stimulated axon regeneration. This study of axon function is scientifically and experimentally

distinct, but complements the current application, which aims to boost the amount of regeneration using novel

molecular approaches and improved gene delivery tools.

 

R21NS106309 Blackmore (PI), Venkatesh (Co-I) 9/2018-8/2021 

Regulation of CNS Regeneration by Chromatin Accessibility and Pioneer Factors

This grant aims to profile changes in chromatin accessibility in CNS neurons across development and in

response to injury. Although one aim of this grant involves testing pioneer factors for effects on axon growth,

the set of factors to be tested are completely distinct from the current proposal, reflecting differences in the

discovery strategy.

 

Bryon Riesch Foundation Blackmore (PI) 4/2019-3/2029

Excellence in Spinal Injury Research

The Bryon Riesch Foundation has generously committed to recurring annual research support for a ten year period.

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endParalysis Foundation (Co-I) 12/2020 - 11/2021

The goal of this project is to advance a promising new gene therapy approach for improving axon growth after spinal injury. It is based on a recent discovery from the Blackmore lab that a combination of two transcription factors, Klf6 and Nr5a2 (KN), stimulates robust and highly reliable growth from corticospinal tract (CST) axons1. The goal now is to push in the direction of translation by determining whether KN is similarly effective in more chronic and clinically relevant model of spinal contusion