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New Paper out in Experimental Neurology! Congratulations Audra!
Promotion of corticospinal tract growth by KLF6 requires an injury stimulus and occurs within four weeks of treatment
Audra Kramer earns her PhD! Congratulations Dr. Kramer!
Combined Gene Therapy and Rehabilitative Approaches to Repair the Corticospinal Tract Following Injury
Preprint now available on BioRxiv!
Computational approaches identify novel transcription factor combinations that promote corticospinal axon growth after injury
First Place Trophy at the Bryon Riesch Paralysis Foundation Team Challenge!
Blackmore lab crew David Nowak, Erik Eastwood and Naveen Jayaprakash presented their research findings at SFN 2018 in San Diego. Their poster was titled " Combined pro-regenerative strategies and targeted rehabilitation to improve behavioral outcomes after spinal cord injury". Check out the abstract here. David Nowak received a TDPA award from SFN this year to attend the meeting. Congrats David!
Dr. Blackmore gave a keynote address at the Midwest Regional Neuroscience Conference held in University of St.Thomas,MN. His talk was titled " Rebooting the growth machinery: Gene therapy approaches to Spinal Cord Injury"
David Nowak from the lab presented his undergraduate research work at the Midwest Regional Neuroscience Conference in a poster titled " Combined pro-regenerative/targeted rehab strategies to improve behavioral outcomes after spinal cord injury".
Graduate student Audra Kramer won second place for her talk at the annual ACUBE meeting. Her talk was titled " Teaching personalized medicine in the classroom : A pharmacological case study based on patient data". Congrats Audra!
New manuscript out in the Journal of Neuroscience!
This work is the result of a fantastic collaboration with Dr.Pantelis Tsoulfas at Miami Project to Cure paralysis.AAV2-Retro is phenomenal! 3D movies of supraspinal pathways, and reversible forelimb paralysis with Retro-Gi-DREADDs. Congrats to the lead author Dr.Zimei Wang!
Dr.Blackmore and Dr.Venkatesh received an NIH R21 to discover novel molecular manipulations to relieve epigenetic constraints in CNS neurons. For more on the funded project, head over to our Bioinformatics research interests, and/or check out our recent manuscript.
Undergrads Lyndsey Holan and David Nowak had a productive summer optimizing protocols to carry out fluorescent in situ hybridization and electrical stimulation experiments. They presented their key findings at the SRP symposium.
Dr.Blackmore secured an R01 to study activity-based therapies and enhance the connections of the regrown nerves, with the goal of increasing motor control and function.
Dr.Venkatesh secured an XSEDE grant from NSF that provides access to high-end computational resources for NGS data analysis, visualization and storage. This will power several new bioinformatic workflows to identify novel genetic/epigenetic strategies to improve regenerative outcomes following SCI.
Summer research program
Dr.Blackmore was invited to give a talk and chair a session at the International Spinal Research Trust network meeting held in London. The title of his talk was "Optimal Transcription factor combinations for axon regeneration in the central nervous system".
Our manuscript on identifying chromatin accessibility as an epigenetic barrier to axon growth is now out in Developmental Neurobiology.
The lab has a new pre-print out on bioRxiv! This work is the result of a fantastic collaboration with Dr.Pantelis Tsoulfas at Miami Project to Cure paralysis.
AAV2-Retro is phenomenal! 3D movies of supraspinal pathways, and reversible forelimb paralysis with Retro-Gi-DREADDs.
The lab has two new pre-prints out on bioRxiv!
Blackmore lab participated in 2 fund raisers for the Bryon Riesch paralysis foundation
Congrats to Dr. Jayaprakash who recently got promoted to Research Assistant Professor!
Dr. Blackmore gave a talk at the Waisman Center at UW-Madison titled "From High Content Screening to In Vivo Testing: The Hunt for Novel Genes to Promote CNS Repair"
Venkatesh and Blackmore, 2017
Selecting optimal combinations of transcription factors to promote axon regeneration: Why mechanisms matter.
Wang et al, 2017
Combined chondroitinase and KLF7 expression reduce net retraction of sensory and CST axonsfrom sites of spinal injury.
Two new papers from the lab!
Congrats to Dr. Jayaprakash on receiving a
post-doctoral fellowship from the Wings for life foundation !
Graduate student Ben Callif successfully defended his Masters dissertation. Congrats Ben!
Summer research program
Undergrads conducted summer research in the lab alongside Dr.Jayaprakash and presented their key findings at the SRP symposium
Data Intensive Biology Summer Institute- 2 week Bioinformatics workshop at UC-Davis
Dr.Venkatesh was selected to attend the NIH-sponsored ANGUS-DIBSI Bioinformatics workshop at UC-Davis
San Diego, CA
Venkatesh et al, 2016
Epigenetic profiling reveals a developmental decrease in promoter accessibility during cortical maturation in vivo.
Callif et al, 2016
The application of CRISPR technology to high content screening in primary neurons
Two new papers from the lab!
Jayaprakash et al, 2016
Optogenetic Interrogation of Functional Synapse Formation by Corticospinal Tract Axons in the Injured Spinal Cord.
New paper out in the Journal of Neuroscience. Congrats Naveen!
Dr. Venkatesh received a post-doctoral fellowship from the Nielsen Foundation for her project titled "Epigenetic regulation of axon growth in mammalian CNS neurons". Congrats Ish!
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